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KMID : 0361019960390040648
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Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 4 p.648 ~ p.654
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Expression of p53 in Squamous Cell Carcinoma of Laryngeal Cancer
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김동욱
박철규/김학준/이병돈/김기환/장혁순/강주원
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Abstract
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Variable methods have been applied to predict the prognosis of cancer patients, one of which is molecular biologic methods.
Many authors have been studing the relation between the basic mechanism of cancer and its prognosis and treatment. Among the material of carcinogenic gene is p53.
To evaluate the relationship between the expression of p53 and variable prognostic factors of laryngeal cancer, 57 cases of pathologically confirmed laryngeal cancer were selected immunohistochemical was done for p53.
@ES The results were as follows:
@EN 1) The overall expression rate of p53 was 36.8%(21/57).
2) The p53 expression rates were higher in supraglottic primary lesions(9/13) than in glottic primary lesion(12/44), however it was not significant statistically.
3) The p53 expression rates were increased by clinical stag, but were not statistically significant.
4) The p53 expression rates were directly related to high nodal stage and poor histologic grade and were statistically significant(p<0.05).
In conclusion, p53 expression rates were related to some clinically prognostic factor and futher studies are needed to substantiate that p53 expression may be considered to be an variable factors in the laryngeal cancer. (Korean J Otolaryngol 39
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4,
1996)
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